abstract：BACKGROUND:Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells...

journal_title：BMC cancer

authors： Quentmeier H,Eberth S,Romani J,Weich HA,Zaborski M,Drexler HG

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients. METHODS:Microvesicle RNA from serum from patients with de-novo primary glioblastoma multiforme (N = 9...

journal_title：BMC cancer

authors： Noerholm M,Balaj L,Limperg T,Salehi A,Zhu LD,Hochberg FH,Breakefield XO,Carter BS,Skog J

更新日期：2012-01-17 00:00:00

abstract：BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...

journal_title：BMC cancer

authors： Zhou Y,Yin X,Ying J,Zhang B

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:Stimulation of vascular endothelial growth factor (VEGF) has been observed following transarterial chemoembolization (TACE) in hepatocellular cancer (HCC) and may contribute to tumor regrowth. This pilot study examined whether intravenous (IV) bevacizumab, a monoclonal antibody against VEGF, could inhibit ne...

journal_title：BMC cancer

authors： Britten CD,Gomes AS,Wainberg ZA,Elashoff D,Amado R,Xin Y,Busuttil RW,Slamon DJ,Finn RS

更新日期：2012-01-14 00:00:00

abstract：BACKGROUND:Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases. METHODS:T-A...

journal_title：BMC cancer

authors： Mansur MB,Hassan R,Barbosa TC,Splendore A,Jotta PY,Yunes JA,Wiemels JL,Pombo-de-Oliveira MS

更新日期：2012-01-06 00:00:00

abstract：BACKGROUND:Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal carcinoma (CCRCC) progression. However, clinical trials with the prototypic Hsp90 inhibitor 17-AAG ha...

journal_title：BMC cancer

authors： Bohonowych JE,Peng S,Gopal U,Hance MW,Wing SB,Argraves KM,Lundgren K,Isaacs JS

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:A universal hallmark of cancer cells is the change in their glycosylation phenotype. One of the most frequent alterations in the normal glycosylation pattern observed during carcinogenesis is the enhancement of α(1,6)linked fucose residues of glycoproteins, due to the up-regulation of the α(1,6)fucosyltransf...

journal_title：BMC cancer

authors： Muinelo-Romay L,Villar-Portela S,Cuevas E,Gil-Martín E,Fernández-Briera A

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival rates of only 50-60%. Neo-adjuvant and adjuvant chemotherapy (CTX) has been applied to achieve pre-...

journal_title：BMC cancer

authors： Schmitt T,Lehner B,Kasper B,Bischof M,Roeder F,Dietrich S,Dimitrakopoulou-Strauss A,Strauss LG,Mechtersheimer G,Wuchter P,Ho AD,Egerer G

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorectal cancer (CRC) patients receiving cetuximab-based therapy. METHODS:Fifty-eight advanced CRC pat...

journal_title：BMC cancer

authors： Dahan L,Norguet E,Etienne-Grimaldi MC,Formento JL,Gasmi M,Nanni I,Gaudart J,Garcia S,Ouafik L,Seitz JF,Milano G

更新日期：2011-11-25 00:00:00

abstract：BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...

journal_title：BMC cancer

authors： Eskew JD,Sadikot T,Morales P,Duren A,Dunwiddie I,Swink M,Zhang X,Hembruff S,Donnelly A,Rajewski RA,Blagg BS,Manjarrez JR,Matts RL,Holzbeierlein JM,Vielhauer GA

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:Analysis of the clinical response of extramedullary lesions in leukemic patients treated with radiation therapy (RT) and defining the optimal dose of radiation. METHODS:Forty-two extramedullary lesions found in 24 leukemic patients treated with RT were reviewed. The radiation was delivered usually 2 Gy/day,...

journal_title：BMC cancer

authors： Song JH,Son SH,Lee JH,Chung SM,Jang HS,Choi BO

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...

journal_title：BMC cancer

authors： Neklason DW,Done MW,Sargent NR,Schwartz AG,Anton-Culver H,Griffin CA,Ahnen DJ,Schildkraut JM,Tomlinson GE,Strong LC,Miller AR,Stopfer JE,Burt RW

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level facto...

journal_title：BMC cancer

authors： Youl PH,Baade PD,Aitken JF,Chambers SK,Turrell G,Pyke C,Dunn J

更新日期：2011-09-28 00:00:00

abstract：:ABSTRACT: BACKGROUND: The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects. METHODS: A questionnaire-based survey of PHC patients in t...

journal_title：BMC cancer

authors： Ramos M,Llagostera M,Esteva M,Cabeza E,Cantero X,Segarra M,Martín-Rabadán M,Artigues G,Torrent M,Taltavull JM,Vanrell JM,Marzo M,Llobera J

更新日期：2011-09-25 00:00:00

abstract：BACKGROUND:The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphom...

journal_title：BMC cancer

authors： Sernbo S,Gustavsson E,Brennan DJ,Gallagher WM,Rexhepaj E,Rydnert F,Jirström K,Borrebaeck CA,Ek S

更新日期：2011-09-24 00:00:00

abstract：BACKGROUND:Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSFs) stimulate neutrophil production and may reduce FN incidence when given prophylactically following...

journal_title：BMC cancer

authors： Cooper KL,Madan J,Whyte S,Stevenson MD,Akehurst RL

更新日期：2011-09-23 00:00:00

abstract：BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...

journal_title：BMC cancer

authors： Le Scodan R,Jouanneau L,Massard C,Gutierrez M,Kirova Y,Cherel P,Gachet J,Labib A,Mouret-Fourme E

更新日期：2011-09-19 00:00:00

abstract：BACKGROUND:This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure (study 2). METHODS:STUDY 1: Items were taken from the literature and reviewed by expert groups. ...

journal_title：BMC cancer

authors： Power E,Simon A,Juszczyk D,Hiom S,Wardle J

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of t...

journal_title：BMC cancer

authors： Li J,Zhang BN,Fan JH,Pang Y,Zhang P,Wang SL,Zheng S,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,Li JY,He JJ,Qiao YL

更新日期：2011-08-22 00:00:00

abstract：BACKGROUND:Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in p...

journal_title：BMC cancer

authors： Pérez-Saldivar ML,Fajardo-Gutiérrez A,Bernáldez-Ríos R,Martínez-Avalos A,Medina-Sanson A,Espinosa-Hernández L,Flores-Chapa Jde D,Amador-Sánchez R,Peñaloza-González JG,Alvarez-Rodríguez FJ,Bolea-Murga V,Flores-Lujano J,Rodríguez-Z

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...

journal_title：BMC cancer

authors： Stavik B,Skretting G,Aasheim HC,Tinholt M,Zernichow L,Sletten M,Sandset PM,Iversen N

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C) and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter usage and alternative...

journal_title：BMC cancer

authors： Malpeli G,Amato E,Dandrea M,Fumagalli C,Debattisti V,Boninsegna L,Pelosi G,Falconi M,Scarpa A

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...

journal_title：BMC cancer

authors： Schaefer IM,Günnel H,Schweyer S,Korenkov M

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is primarily responsible for the increased overall incidence of thyroid cancer. Sorafenib is a multikinase i...

journal_title：BMC cancer

authors： Brose MS,Nutting CM,Sherman SI,Shong YK,Smit JW,Reike G,Chung J,Kalmus J,Kappeler C,Schlumberger M

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...

journal_title：BMC cancer

authors： Peric B,Zagar I,Novakovic S,Zgajnar J,Hocevar M

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization study found that the two regimens had similar costs from a healthcare provider perspective but XELOX had...

journal_title：BMC cancer

authors： Tse VC,Ng WT,Lee V,Lee AW,Chua DT,Chau J,McGhee SM

更新日期：2011-07-09 00:00:00

abstract：BACKGROUND:Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endot...

journal_title：BMC cancer

authors： Porquet N,Poirier A,Houle F,Pin AL,Gout S,Tremblay PL,Paquet ER,Klinck R,Auger FA,Huot J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Extrahepatic biliary duct cancers (EBDC) are uncommon malignancies characterized by a poor prognosis with high rate of loco-regional recurrence. The purpose of the present study is to assess the feasibility and the potential impact of adjuvant radiotherapy (RT) in a series of patients treated in one institut...

journal_title：BMC cancer

authors： Bonet Beltrán M,Roth AD,Mentha G,Allal AS

更新日期：2011-06-24 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the incidence and prognostic value of disseminated tumor cells in bone marrow of breast carcinoma patients with early disease, and to analyze this finding in relation to lymph node involvement, determined by sentinel lymph node (SLN) biopsy analysis, and to prognostic...

journal_title：BMC cancer

authors： Solá M,Margelí M,Castellá E,Julian JF,Rull M,Gubern JM,Mariscal A,Barnadas A,Fraile M

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. However, the majority of hu...

journal_title：BMC cancer

authors： Ohnstad HO,Paulsen EB,Noordhuis P,Berg M,Lothe RA,Vassilev LT,Myklebost O

更新日期：2011-05-30 00:00:00

abstract：BACKGROUND:Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence suggests that the expression level of histamine receptor H4 (HRH4) is abnormal in colorectal cancer tissu...

journal_title：BMC cancer

authors： Fang Z,Yao W,Xiong Y,Li J,Liu L,Shi L,Zhang W,Zhang C,Nie L,Wan J

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of l...

journal_title：BMC cancer

authors： Grutsch JF,Ferrans C,Wood PA,Du-Quiton J,Quiton DF,Reynolds JL,Ansell CM,Oh EY,Daehler MA,Levin RD,Braun DP,Gupta D,Lis CG,Hrushesky WJ

更新日期：2011-05-23 00:00:00

abstract：BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...

journal_title：BMC cancer

authors： Jensen AD,Krauss J,Potthoff K,Desta A,Habl G,Mavtratzas A,Windemuth-Kiesselbach C,Debus J,Münter MW

更新日期：2011-05-19 00:00:00

abstract：BACKGROUND:Weekly docetaxel has occasionally been used in the neoadjuvant to downstage breast cancer to reduce toxicity and possibly enhance quality of life. However, no studies have compared the standard three weekly regimen to the weekly regimen in terms of quality of life. The primary aim of our study was to compare...

journal_title：BMC cancer

authors： Walker LG,Eremin JM,Aloysius MM,Vassanasiri W,Walker MB,El-Sheemy M,Cowley G,Beer J,Samphao S,Wiseman J,Jibril JA,Valerio D,Clarke DJ,Kamal M,Thorpe GW,Baria K,Eremin O

更新日期：2011-05-18 00:00:00

abstract：BACKGROUND:Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. ...

journal_title：BMC cancer

authors： Yoon HH,Catalano PJ,Murphy KM,Skaar TC,Philips S,Powell M,Montgomery EA,Hafez MJ,Offer SM,Liu G,Meltzer SJ,Wu X,Forastiere AA,Benson AB,Kleinberg LR,Gibson MK

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch o...

journal_title：BMC cancer

authors： Patrelli TS,Silini EM,Gizzo S,Berretta R,Franchi L,Thai E,Lukanovic A,Nardelli GB,Modena AB

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in distinct cancer entities can be determined by a comprehensive expression analysis of the 13 human AQPs....

journal_title：BMC cancer

authors： Warth A,Muley T,Meister M,Herpel E,Pathil A,Hoffmann H,Schnabel PA,Bender C,Buness A,Schirmacher P,Kuner R

更新日期：2011-05-06 00:00:00

abstract：BACKGROUND:Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected luminal, post-EMT and basal-like breast carcinoma cell lines. METHODS:Migration was assessed in luminal (...

journal_title：BMC cancer

authors： Voss MJ,Möller MF,Powe DG,Niggemann B,Zänker KS,Entschladen F

更新日期：2011-05-02 00:00:00